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Targeted Therapeutics in Melanoma / F. Stephen Hodi ; Thomas F. Gajewski

PPN=1746460873; in Bibliotheksbestand, Treffer: 1

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MedienartE-Book [E-Book]
VerfasserHodi, F. Stephen
Titel Targeted Therapeutics in Melanoma / F. Stephen Hodi ; Thomas F. Gajewski
PersonGajewski, Thomas F.
VeröffentlichungTotowa, NJ : Humana Press, 2011
©2012
Umfang / Format 1 online resource (376 pages)
Anmerkungen Description based on publisher supplied metadata and other sources.
SpracheEnglisch
ISBN9781617794070
NummerEBL884435 (EBL)
ebr10520958 (EBR)
MIL344772 (MYL)
EBC884435 (EBC)
029390508 (EBP)
1746460873 (K10Plus-Nummer)
Schriftenreihe (Current Clinical Oncology Ser.)
Schlagwörter Melanoma
Electronic books
Inhalt This book describes recent ground-breaking developments in melanoma treatment in the arena of targeted therapeutics. The contents explore both established signal transduction inhibitors and the fascinating emerging realm of molecularly-guided immunotherapies.
Inhalt Intro -- Targeted Therapeutics in Melanoma -- Preface -- Cracking the Melanoma Nut -- Acknowledgments -- Contents -- Contributors -- Part I: Advances in Melanoma Biology -- Chapter 1: Molecular Targets and Subtypes in Melanoma -- Introduction -- BRAF -- NRAS -- PI3K-AKT Pathway -- c-KIT -- GNAQ -- Conclusions -- References -- Chapter 2: Melanoma Genomics -- Gene Expression Profiling of Distinct Phases of Melanoma Progression -- Gene Expression Profiles of Primary Melanoma -- Gene Expression Profiling of Metastatic Melanoma -- Conclusions -- References -- Chapter 3: Predictive Biomarkers as a Guide to Future Therapy Selection in Melanoma -- Evidence for Existence of Biologic Subsets of Melanoma -- Kinase Mutations and Clinical Response to Kinase Inhibitors -- B-Raf -- c-kit -- New Pathways Showing Heterogeneity Among Individual Melanoma Patients -- Gene Expression Profiling and Clinical Response to Melanoma Vaccines -- Molecular Features Associated with Response to Chemotherapy -- Biomarkers as a Tool to Determine Mechanisms of Therapeutic Resistance -- Predictive Biomarkers from Non-Tumor Tissue: Serum and Germline DNA -- The Evolving Future of Melanoma Therapy -- References -- Part II: Signaling Molecules as Molecular Targets -- Chapter 4: KIT as a Therapeutic Target for Melanoma -- Introduction -- KIT as a Proto-Oncogene -- The Role of KIT in Cancer -- KIT Tyrosine Kinase Inhibitors -- Overcoming Resistance to Tyrosine Kinase Inhibition -- Is KIT Amplification or Mutation More Important? -- Conclusions -- References -- Chapter 5: Targeted Inhibition of B-Raf -- Introduction -- The MAPK Pathway -- BRAF Mutations in Melanoma -- Preclinical Studies -- RAF Inhibition of BRAF Wild-Type Cells Leads to Activation of the MAPK Pathway -- RAF Inhibition of BRAF-Mutated Melanoma Causes Melanoma Cell Death.

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